Les effets du champ magnétique sur les propriétés optiques des composés photosensibles de la thérapie photodynamique, qui combinent à la fois les fonctionnalités thérapeutique d’un médicament et diagnostique d’une molécule-sonde, ont été démontrés avec les agents PDT développés par le client pour extraire et suivre d’une façon dynamique l’oxygénation et/ou d’autres formes d’oxygène moléculaire réactif.
Photodynamic Therapy
Publications
Noiseux, I., Mermut, O., Bouchard, J.-P., Cormier, J.-F., Desroches, P., Fortin, M., Gallant, P., Leclair, S., Vernon, M., Diamond K. R., Patterson,M.S. “Effect of liposomal confinement on photochemical properties of photosensitizers with varying hydrophilicity” J. Biomed. Opt., 13(4), 041313, 2008.
Mermut, O., Noiseux, I., Bouchard, J.-P., Cormier, J.-F., Desroches, P., Fortin, M., Gallant, P., Leclair, S., Vernon, M., Diamond K. R., Patterson MS. “Effect of liposomal confinement on photo-thermal and photo-oximetric fluorescence lifetimes of photosensitizers with varying hydrophilicity” J. Biomed. Opt., 13(4), 041314, 2008.
Mermut O, Diamond KR, Cormier JF, Gallant P, Hô N, Leclair S, Marois JS, Noiseux I, Morin JF, Patterson MS, Vernon ML. “The Use of Magnetic Field Effects on Photosensitizer Luminescence as a Novel Probe for Optical Monitoring of Oxygen in Photodynamic Therapy” Phys. Med. Biol., accepted 2008.
Mermut O, Noiseux I, Bouchard JP, Cormier JF, Desroches P, Fortin M, Gallant P, Leclair S, Vernon M, Diamond KR, Patterson MS. “Effect of liposomal confinement on photo-thermal and photo-oximetric fluorescence lifetimes of photosensitizers with varying hydrophilicity” Virtual Journal of Biological Physics Research 16(2) 2008.
Mermut, O., Bouchard, J.-P., Cormier, J.-F., Desroches, P., Fortin, M., Gallant, P., Leclair, S., Noiseux, I., Vernon, M., Diamond K.R., Patterson, M.S. "Use of Magnetic Fields to Probe and Alter Photodynamic Processes in Photosensitizers," in Biomedical Optics, Optical Society of America (OSA) Technical Digest, paper BWB4, 2008
Mermut, O., Bouchard, J.-P., Cormier, J.-F., Desroches, P., Diamond K. R., Fortin, M., Gallant, P., Leclair, S.; Marois J.S., Noiseux, I., Morin J.-F, Patterson M.S., Vernon, M., “Time-resolved luminescence measurements of the magnetic field effect on paramagnetic photosensitizers in photodynamic reactions”, in New Sensitizers, Proc. of SPIE, vol. 6845 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic, paper 68450T, 2008.
Mermut, O., Bouchard, J.-P., Cormier, J.-F., Diamond K. R., Noiseux, I., Vernon, M.L and Patterson M.S. "Frequency domain, time-resolved and spectroscopic investigations of photosensitizers encapsulated in liposomal phantoms," in Therapeutic Laser Applications and Laser-Tissue Interactions III, Proc. of SPIE Volume 6632 - Progress In Biomedical Optics And Imaging, (OSA) paper 663218, 2007.
Mermut, O., Bouchard, J.-P., Cormier, J.-F., Diamond, K.R., Gallant, P., Noiseux, I., Vernon, M., Patterson M.S. “Frequency domain, time-resolved and spectroscopic investigations of photosensitizing drugs encapsulated in liposomal phantoms” in Biophotonics 2007, Vol. 3, 21, 2007.
Conférences
Mermut, O. “The effect of magnetic fields on photodynamic processes in cancer phototherapy” Gordon Research Conference - Lasers in Medicine and Biology, Holderness, NH, USA, July 20-25 2008.
Mermut, O. “Biophotonics Research and Innovation” Canadian Organization of Medical Physicists Annual Meeting, Quebec City, Canada, June 25-28 2008.
Mermut, O.“Time-resolved luminescence measurements of the magnetic field effect on paramagnetic photosensitizers in photodynamic reactions”, Engineering Conferences International: Biochemical Engineering XV. Controlled liposomal systems for photodynamic therapy and pharmaceutical applications, Quebec City, Canada, July 15-19 2007